2-(3-Bromophenyl)imidazo[2,1-b]oxazole

نویسندگان

چکیده

The microwave-assisted reaction of 2-nitroimidazole with 3-bromophenacyl bromide in the presence potassium carbonate as a base and dimethylformamide solvent afforded 2-(3-bromophenyl)imidazo[2,1-b]oxazole. formation this compound was explained via domino mechanism comprising an initial N-alkylation imidazole substrate, followed by base-promoted deprotonation position adjacent to carbonyl give enolate anion that finally cyclizes intramolecular SNAr reaction, loss nitro group nitrite. Then, proposed 1-(3-bromophenacyl)-2-nitroimidazole intermediate could be isolated reducing time shown precursor imidazo[2,1-b]oxazole final product.

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ژورنال

عنوان ژورنال: Molbank

سال: 2023

ISSN: ['1422-8599']

DOI: https://doi.org/10.3390/m1616